Selected article for: "M1 virus PPxY mutation and ppxy motif"
Author: Wodrich, Harald; Henaff, Daniel; Jammart, Baptist; Segura-Morales, Carolina; Seelmeir, Sigrid; Coux, Olivier; Ruzsics, Zsolt; Wiethoff, Christopher M.; Kremer, Eric J.
Title: A Capsid-Encoded PPxY-Motif Facilitates Adenovirus Entry
  • Document date: 2010_3_19
    • ID: 1mjmttec_42
    Snippet: Earlier studies have shown that PPxY type late domains bind to ubiquitin ligases of the Nedd4 family rather then directly to class E VSP proteins [13] . Our study showed that the PPxY motif in protein VI can interact with all Nedd4 ligases tested but preferentially binds to Nedd4.1 and Nedd4.2 and re-targets them to membranes. Owing to topological constrains, recognition of the PPxY domain should require membrane rupture because of the cytosolic .....
    Document: Earlier studies have shown that PPxY type late domains bind to ubiquitin ligases of the Nedd4 family rather then directly to class E VSP proteins [13] . Our study showed that the PPxY motif in protein VI can interact with all Nedd4 ligases tested but preferentially binds to Nedd4.1 and Nedd4.2 and re-targets them to membranes. Owing to topological constrains, recognition of the PPxY domain should require membrane rupture because of the cytosolic localization of Nedd4 ligases, which according to our data does not seem to be affected by the PPxY mutation in the M1 virus.

    Search related documents:
    Co phrase search for related documents
    • late domain and ppxy domain: 1, 2, 3, 4, 5, 6
    • late domain and PPxY motif: 1, 2, 3, 4
    • late domain and protein PPxY motif: 1
    • M1 virus and membrane target: 1
    • M1 virus and ppxy domain: 1
    • M1 virus and PPxY motif: 1, 2, 3, 4, 5
    • M1 virus and PPxY mutation: 1, 2
    • M1 virus and protein PPxY motif: 1, 2, 3, 4, 5
    • M1 virus PPxY mutation and ppxy domain: 1
    • M1 virus PPxY mutation and PPxY motif: 1, 2
    • M1 virus PPxY mutation and PPxY mutation: 1, 2
    • M1 virus PPxY mutation and protein PPxY motif: 1, 2
    • ppxy domain and protein PPxY motif: 1, 2, 3, 4
    • PPxY motif and protein PPxY motif: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22
    • PPxY mutation and protein PPxY motif: 1, 2, 3