Author: Wodrich, Harald; Henaff, Daniel; Jammart, Baptist; Segura-Morales, Carolina; Seelmeir, Sigrid; Coux, Olivier; Ruzsics, Zsolt; Wiethoff, Christopher M.; Kremer, Eric J.
Title: A Capsid-Encoded PPxY-Motif Facilitates Adenovirus Entry Document date: 2010_3_19
ID: 1mjmttec_45
Snippet: Release and separation of protein VI from the capsid is clearly defective in the Ad5-VI-M1 mutant virus. A lack of functional PPxY may therefore block disassembly steps, preclude efficient endosomal escape following the membrane lysis event or fail in the recruitment of subsequent factors required to efficiently link the virus with retrograde transport pathways. Penton base also encodes PPxY motifs [49] . Because eliminating the PPxY motif from p.....
Document: Release and separation of protein VI from the capsid is clearly defective in the Ad5-VI-M1 mutant virus. A lack of functional PPxY may therefore block disassembly steps, preclude efficient endosomal escape following the membrane lysis event or fail in the recruitment of subsequent factors required to efficiently link the virus with retrograde transport pathways. Penton base also encodes PPxY motifs [49] . Because eliminating the PPxY motif from protein VI had only modest effects on MTOC accumulation, there may be functional overlap between the PPxY in protein VI and penton base. This is further supported by the observation that ubiquitylation of penton could be abolished by depleting the cytosol with protein VI indicating that maybe the same ligases are involved ( Figure S5 ).
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