Selected article for: "PPxY motif and protein PPxY motif"
Author: Wodrich, Harald; Henaff, Daniel; Jammart, Baptist; Segura-Morales, Carolina; Seelmeir, Sigrid; Coux, Olivier; Ruzsics, Zsolt; Wiethoff, Christopher M.; Kremer, Eric J.
Title: A Capsid-Encoded PPxY-Motif Facilitates Adenovirus Entry
  • Document date: 2010_3_19
    • ID: 1mjmttec_4
    Snippet: Nedd4.1 and its close relative Nedd4.2 are prototypic members of this family, which is conserved from yeast to mammals [16] . They encode a N-terminal C2 domain for Ca 2+ -dependent lipid interaction, a catalytical HECT domain and three to four WWdomains for protein-protein interactions with proline-rich domains such as the PPxY motif [16, 17] . The exact role of PPxYrecruitment of Nedd4 ligases in VSP-mediated viral budding is still unclear. A p.....
    Document: Nedd4.1 and its close relative Nedd4.2 are prototypic members of this family, which is conserved from yeast to mammals [16] . They encode a N-terminal C2 domain for Ca 2+ -dependent lipid interaction, a catalytical HECT domain and three to four WWdomains for protein-protein interactions with proline-rich domains such as the PPxY motif [16, 17] . The exact role of PPxYrecruitment of Nedd4 ligases in VSP-mediated viral budding is still unclear. A possible link was recently shown by enhanced ESCRT ubiquitylation through Nedd4.2 overexpression [18, 19] .

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