Author: Ackerman, Emily E.; Alcorn, John F.; Hase, Takeshi; Shoemaker, Jason E.
Title: A dual controllability analysis of influenza virus-host protein-protein interaction networks for antiviral drug target discovery Document date: 2019_6_3
ID: 0wfaggvo_18
Snippet: Robust controllability was calculated (see Methods) for all proteins of the HIN and VIN (as shown in Table 2 with and without parentheses, respectively). The addition of IAV interactions to the network has no effect on the distribution of classifications of host proteins, and consequently, the IAV Interacting proteins. Upon entry to the VIN, the 11 IAV proteins are classified as neutral, meaning that removing these proteins does not alter the num.....
Document: Robust controllability was calculated (see Methods) for all proteins of the HIN and VIN (as shown in Table 2 with and without parentheses, respectively). The addition of IAV interactions to the network has no effect on the distribution of classifications of host proteins, and consequently, the IAV Interacting proteins. Upon entry to the VIN, the 11 IAV proteins are classified as neutral, meaning that removing these proteins does not alter the number of driver proteins required to control the VIN (N D = N D '). This reveals that the removal of singular proteins from the system is not enough to disturb the existing control structure under robust controllability.
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