Selected article for: "immunogenic peptide and influenza virus"
Author: Shehata, Mahmoud M.; Kandeil, Ahmed; Mostafa, Ahmed; Mahmoud, Sara H.; Gomaa, Mokhtar R.; El-Shesheny, Rabeh; Webby, Richard; Kayali, Ghazi; A. Ali, Mohamed
Title: A Recombinant Influenza A/H1N1 Carrying A Short Immunogenic Peptide of MERS-CoV as Bivalent Vaccine in BALB/c Mice
  • Document date: 2019_12_2
    • ID: 15q6qr4z_16
    Snippet: Reverse genetics was used for generation of recombinant influenza virus since it allows manipulation of influenza virus genome by addition, change, or removal of genetic determinants responsible for virus virulence. The short immunogenic peptide was inserted in the stalk region of NA from H1N1pdm09 using recombinant ligation. Influenza as a viral vector system for MERS-CoV has potential advantages including the ability for large-scale production .....
    Document: Reverse genetics was used for generation of recombinant influenza virus since it allows manipulation of influenza virus genome by addition, change, or removal of genetic determinants responsible for virus virulence. The short immunogenic peptide was inserted in the stalk region of NA from H1N1pdm09 using recombinant ligation. Influenza as a viral vector system for MERS-CoV has potential advantages including the ability for large-scale production of engineered virus in embryonated chicken eggs and stimulation of mucosal and systemic immune responses [18] . In our study, we used inactivated influenza vaccination due to its safety measure in comparison with influenza live attenuated vaccine (ILAV) which causes influenza like-illness (headache, runny nose, sore throat, and cough) and ILAV was limited in pregnant and immune-compromised patients [19] .

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