Author: Hu, Hao-Teng; Cho, Che-Pei; Lin, Ya-Hui; Chang, Kung-Yao
Title: A general strategy to inhibiting viral -1 frameshifting based on upstream attenuation duplex formation Document date: 2016_1_8
ID: 1u10lpx2_39
Snippet: Outbreak of the SARS-CoV at Asia in 2013 was followed by the emergence of MERS-CoV in the Kingdom of Saudi Arabia 10 years later. Both virologists and epidemiologists predict that there will be more and more novel human coronaviruses emerging due to rapid mutation of viral genomes and the zoonotic features (54) (55) . Unfortunately, there is no approved vaccine for SARS or MERS. Therefore, the development of an antiviral strategy for rapid respon.....
Document: Outbreak of the SARS-CoV at Asia in 2013 was followed by the emergence of MERS-CoV in the Kingdom of Saudi Arabia 10 years later. Both virologists and epidemiologists predict that there will be more and more novel human coronaviruses emerging due to rapid mutation of viral genomes and the zoonotic features (54) (55) . Unfortunately, there is no approved vaccine for SARS or MERS. Therefore, the development of an antiviral strategy for rapid response to the emerging coronavirus infection is important. Antiviral approaches against viral −1 PRF have been targeting on the downstream stimulators (20) (21) (22) . Although small-molecule drugs provide uptake advantage, detailed structural information of the stimulator RNA is needed for this approach. Unfortunately, no high resolution −1 PRF stimulator structure of hCoV is available. Recently, three-dimensional RNA structure modeling of SARS-CoV −1 PRF stimulator pseudoknot in combination with computer-aided drug library modeling and screening have helped identifying potential leads for the inhibition of SARS-CoV −1 PRF (25) . However, the proposed binding pocket of the leads seems to be specific for SARS-CoV pseudoknot stimulator (25) .
Search related documents:
Co phrase search for related documents- antiviral approach and bind pocket: 1
- antiviral approach and coronavirus infection: 1, 2, 3, 4, 5, 6, 7
- antiviral approach and rapid response: 1
- antiviral approach and small molecule: 1, 2, 3, 4, 5, 6
- antiviral approach and structure modeling: 1
- antiviral approach and viral genome: 1, 2, 3
- antiviral strategy and coronavirus infection: 1, 2, 3, 4, 5
- antiviral strategy and drug library: 1
- antiviral strategy and small molecule: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
- antiviral strategy and structure modeling: 1, 2
- antiviral strategy and viral genome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- approach need and coronavirus infection: 1, 2, 3, 4, 5, 6, 7
- approach need and high resolution: 1
- approach need and rapid response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- approach need and small molecule: 1, 2, 3, 4, 5
- approach need and structure modeling: 1
- approach need and viral genome: 1, 2, 3
- bind pocket and coronavirus infection: 1, 2
- bind pocket and drug library: 1, 2
Co phrase search for related documents, hyperlinks ordered by date