Author: Aran Singanayagam; Su-Ling Loo; Maria Calderazzo; Lydia J Finney; Maria-Belen Trujillo Torralbo; Eteri Bakhsoliani; Jason Girkin; Punnam Veerati; Prabuddha S Pathinayake; Kristy S Nichol; Andrew Reid; Joseph Foottit; Sebastian L Johnston; Nathan W Bartlett; Patrick Mallia
Title: Anti-microbial immunity is impaired in COPD patients with frequent exacerbations Document date: 2019_5_9
ID: 72jzqm86_49
Snippet: Our study provides the first evidence that frequent exacerbators have innate anti-viral immune dysfunction, suggesting that a reduction in interferon production might underlie an augmented propensity to virus infections and thus increased exacerbation frequency observed in these patients. This mechanism is supported by a clinical study which reported that COPD patients who are frequent exacerbators experience significantly more coryzal episodes t.....
Document: Our study provides the first evidence that frequent exacerbators have innate anti-viral immune dysfunction, suggesting that a reduction in interferon production might underlie an augmented propensity to virus infections and thus increased exacerbation frequency observed in these patients. This mechanism is supported by a clinical study which reported that COPD patients who are frequent exacerbators experience significantly more coryzal episodes than infrequent exacerbators 26 . Given that inhaled IFN-β therapy has been shown to confer clinical benefit in a subgroup of severe asthmatic patients who develop a cold 27 , our data raises suggestion that such innate immune-boosting therapies could be effective when used in a targeted manner in patients with COPD with evidence of frequent exacerbations and a less effective innate immune response.
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