Author: Liu, Margaret A.
Title: A Comparison of Plasmid DNA and mRNA as Vaccine Technologies Document date: 2019_4_24
ID: 0fx1b7ph_51
Snippet: Prophylactic vaccine human trials for infectious diseases utilizing mRNA encoding the antigen(s) are shown in Table 3 . These are all Phase I trials. Any known formulations are listed, as are any described results and references, along with the clinical trials identifier numbers. The rabies vaccine effort utilizing a licensed vaccine with RNA as the adjuvant (discussed above, and listed in Table 4 ) was replaced by a vaccine using mRNA encoding t.....
Document: Prophylactic vaccine human trials for infectious diseases utilizing mRNA encoding the antigen(s) are shown in Table 3 . These are all Phase I trials. Any known formulations are listed, as are any described results and references, along with the clinical trials identifier numbers. The rabies vaccine effort utilizing a licensed vaccine with RNA as the adjuvant (discussed above, and listed in Table 4 ) was replaced by a vaccine using mRNA encoding the rabies virus glycoprotein. Following either i.d. or i.m. injection of this rabies mRNA vaccine, boostable antibodies were obtained. However, 78% of each group had "solicited systemic adverse events" including ten patients (~10% of all injected patients) with grade three (i.e., serious but not life-threatening) adverse events, although the conclusion was that the vaccine was "generally safe with a reasonable tolerability profile" [55] . A second construct for rabies is now in clinical testing.
Search related documents:
Co phrase search for related documents- adverse event and clinical trial: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72
- adverse event and human trial: 1, 2
- adverse event and identifier number: 1, 2, 3
- adverse event and infectious disease: 1, 2, 3, 4, 5, 6, 7
- adverse event and injection follow: 1
- adverse event and licensed vaccine: 1, 2
- adverse event and mRNA vaccine: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20
- adverse event and tolerability profile: 1, 2, 3, 4, 5, 6
- clinical testing and infectious disease: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58
- clinical testing and licensed vaccine: 1, 2
- clinical testing and mRNA vaccine: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- clinical testing and Prophylactic vaccine: 1
- clinical testing and tolerability profile: 1
- clinical testing and virus glycoprotein: 1, 2
- clinical trial and human trial: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63
- clinical trial and identifier number: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18
- clinical trial and infectious disease: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61
- clinical trial and injection follow: 1, 2
- clinical trial and licensed vaccine: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
Co phrase search for related documents, hyperlinks ordered by date