Author: Wodrich, Harald; Henaff, Daniel; Jammart, Baptist; Segura-Morales, Carolina; Seelmeir, Sigrid; Coux, Olivier; Ruzsics, Zsolt; Wiethoff, Christopher M.; Kremer, Eric J.
Title: A Capsid-Encoded PPxY-Motif Facilitates Adenovirus Entry Document date: 2010_3_19
ID: 1mjmttec_7
Snippet: In epithelial cells, Ad serotype 5 (Ad5) particles undergo stepwise disassembly during entry, starting with detachment of the fiber at or near the cell surface and followed by a passage through endosomal compartments in which acidification serves as additional disassembly trigger for membrane penetration and cytosolic translocation [26, 27] . Partial disassembly releases the internal capsid protein VI, which can lyse membranes in vitro via its pr.....
Document: In epithelial cells, Ad serotype 5 (Ad5) particles undergo stepwise disassembly during entry, starting with detachment of the fiber at or near the cell surface and followed by a passage through endosomal compartments in which acidification serves as additional disassembly trigger for membrane penetration and cytosolic translocation [26, 27] . Partial disassembly releases the internal capsid protein VI, which can lyse membranes in vitro via its predicted N-terminal amphipathic helix [28] . In the cytosol, the particle engages in microtubule-directed transport towards the MTOC and is translocated to the nuclear pore complex (NPC) for nuclear import of the genome [29] [30] [31] .
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