Author: Liu, Margaret A.
Title: A Comparison of Plasmid DNA and mRNA as Vaccine Technologies Document date: 2019_4_24
ID: 0fx1b7ph_67
Snippet: 1) Amplification to protein antigen per molecule of mRNA is less than that per molecule of plasmid DNA (although the entry into the cytosol is one membrane fewer than needs to be traversed for plasmid DNA) 2) mRNA needs to escape the endosome (but does not need entry into the nucleus, whereas plasmid DNA does) 3).....
Document: 1) Amplification to protein antigen per molecule of mRNA is less than that per molecule of plasmid DNA (although the entry into the cytosol is one membrane fewer than needs to be traversed for plasmid DNA) 2) mRNA needs to escape the endosome (but does not need entry into the nucleus, whereas plasmid DNA does) 3)
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