Author: Claus, Claudia; Manssen, Lena; Hübner, Denise; Roßmark, Sarah; Bothe, Viktoria; Petzold, Alice; Große, Claudia; Reins, Mareen; Mankertz, Annette; Frey, Teryl K.; Liebert, Uwe G.
Title: Activation of the Mitochondrial Apoptotic Signaling Platform during Rubella Virus Infection Document date: 2015_11_26
ID: 1rrm4sqa_12
Snippet: The mitochondrial cyclophilin D (CypD) is a discussed regulatory component of the mPTP [21] [22] [23] . Taking this into account, the CPE induction by RV was assessed after overexpression of CypD and its PPIase mutants H168Q and R97A lacking the catalytic function as a peptidyl-prolyl isomerase. Figure 2E shows, that at 3 dpi and in comparison to the vector control (pcDNA3), overexpression of CypD and its PPIase mutants H168Q and R97A increases t.....
Document: The mitochondrial cyclophilin D (CypD) is a discussed regulatory component of the mPTP [21] [22] [23] . Taking this into account, the CPE induction by RV was assessed after overexpression of CypD and its PPIase mutants H168Q and R97A lacking the catalytic function as a peptidyl-prolyl isomerase. Figure 2E shows, that at 3 dpi and in comparison to the vector control (pcDNA3), overexpression of CypD and its PPIase mutants H168Q and R97A increases the number of floaters present in the supernatant of RV-infected Vero cells. In summary, at late time points of infection, RV induces a partial opening of the mPTP. Number of floaters was determined at 3 dpi in comparison to the vector control (pcDNA3). SC, solvent control; scale bar, 20 μm. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.
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