Selected article for: "conformational rearrangement and fusion peptide"
Author: Jones, Harrison G.; Battles, Michael B.; Lin, Chun-Chi; Bianchi, Siro; Corti, Davide; McLellan, Jason S.
Title: Alternative conformations of a major antigenic site on RSV F
  • Document date: 2019_7_15
    • ID: 1r20hl2b_25
    Snippet: Comparison of two prefusion-stabilized RSV F variants, DS (PDB ID: 4MMQ) and Cav1 (PDB ID: 4MMS), highlights the flexibility of site Ø and suggests that a conformational rearrangement of site Ø is required prior to release of the fusion peptide from the central cavity of the trimer during refolding from the prefusion to postfusion state [40] . When only the fusion peptide was anchored by a disulfide bond in the DS structure (PDB ID: 4MMQ), site.....
    Document: Comparison of two prefusion-stabilized RSV F variants, DS (PDB ID: 4MMQ) and Cav1 (PDB ID: 4MMS), highlights the flexibility of site Ø and suggests that a conformational rearrangement of site Ø is required prior to release of the fusion peptide from the central cavity of the trimer during refolding from the prefusion to postfusion state [40] . When only the fusion peptide was anchored by a disulfide bond in the DS structure (PDB ID: 4MMQ), site Ø was acid sequence of residues near RSV F site Ø is shown for both strain A2 and strain B9320. Diamond symbols above each residue indicate a contact between D25 and prefusion RSV F strain A2 based upon PDBePISA analysis of the crystal structure.

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