Author: Criscuolo, E.; Caputo, V.; Diotti, R. A.; Sautto, G. A.; Kirchenbaum, G. A.; Clementi, N.
Title: Alternative Methods of Vaccine Delivery: An Overview of Edible and Intradermal Vaccines Document date: 2019_3_4
ID: 0xo2fiop_24
Snippet: 1.6. Whole-Cell Yeast-Based Vaccines. The industrial usage of yeasts cells for production of heterologous proteins has been well described [63, 64] . Additionally, the capability of this system to perform posttranslational modifications, the GRAS status, and the cellular wall that could protect the antigen across the GIT make engineered yeasts an attractive vaccine delivery system [23, 65] . In addition, the major drawback of this system is hyper.....
Document: 1.6. Whole-Cell Yeast-Based Vaccines. The industrial usage of yeasts cells for production of heterologous proteins has been well described [63, 64] . Additionally, the capability of this system to perform posttranslational modifications, the GRAS status, and the cellular wall that could protect the antigen across the GIT make engineered yeasts an attractive vaccine delivery system [23, 65] . In addition, the major drawback of this system is hyperglycosylation of recombinant proteins, but it has been already addressed by generating defective N-glycosylation strains of yeasts [66, 67] .
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