Author: Meliopoulos, Victoria A.; Van de Velde, Lee-Ann; Van de Velde, Nicholas C.; Karlsson, Erik A.; Neale, Geoff; Vogel, Peter; Guy, Cliff; Sharma, Shalini; Duan, Susu; Surman, Sherri L.; Jones, Bart G.; Johnson, Michael D. L.; Bosio, Catharine; Jolly, Lisa; Jenkins, R. Gisli; Hurwitz, Julia L.; Rosch, Jason W.; Sheppard, Dean; Thomas, Paul G.; Murray, Peter J.; Schultz-Cherry, Stacey
Title: An Epithelial Integrin Regulates the Amplitude of Protective Lung Interferon Responses against Multiple Respiratory Pathogens Document date: 2016_8_9
ID: 16e99fuz_14
Snippet: doi:10.1371/journal.ppat.1005804.g002 mechanism. Adoptive transfer of congenically marked WT AM into β6 KO animals led to the CD11c + CD11b + AM phenotype after 7 days while transfer of β6 KO AMs into WT animals results in a WT CD11c hi CD11bphenotype (Fig 6A-6C) . Importantly, the effect of the β6 KO lung microenvironment was not unique to transferred AM. Adoptive transfer of peritoneal resident macrophages into β6 KO animals resulted in con.....
Document: doi:10.1371/journal.ppat.1005804.g002 mechanism. Adoptive transfer of congenically marked WT AM into β6 KO animals led to the CD11c + CD11b + AM phenotype after 7 days while transfer of β6 KO AMs into WT animals results in a WT CD11c hi CD11bphenotype (Fig 6A-6C) . Importantly, the effect of the β6 KO lung microenvironment was not unique to transferred AM. Adoptive transfer of peritoneal resident macrophages into β6 KO animals resulted in conversion into the CD11c + CD11b + AM phenotype (Fig 6D and 6E ) highlighting that it is the altered lung microenvironment of the β6 KO that controls AM phenotype. Donor cell recovery was consistent for all experiments (S5 Fig) .
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