Author: Geng, HeYuan; Tan, WenJie
Title: A novel human coronavirus: Middle East respiratory syndrome human coronavirus Document date: 2013_8_7
ID: 08ds967z_17
Snippet: To date, a total of 61 laboratory-confirmed cases of infection with MERS-CoV have been reported from Jordan, Qatar, Saudi Arabi, the United Arab Emirates (UAE), France, Germany, Italy and the United Kindom, including 34 deaths. The clinical presentation of acute pneumonia and renal failure observed in the fatal cases resembled SARS-CoV that outbroke in 2002ï€2003. MERS-CoV does not use the angiotensin converting enzyme 2 (ACE2) as a receptor for.....
Document: To date, a total of 61 laboratory-confirmed cases of infection with MERS-CoV have been reported from Jordan, Qatar, Saudi Arabi, the United Arab Emirates (UAE), France, Germany, Italy and the United Kindom, including 34 deaths. The clinical presentation of acute pneumonia and renal failure observed in the fatal cases resembled SARS-CoV that outbroke in 2002ï€2003. MERS-CoV does not use the angiotensin converting enzyme 2 (ACE2) as a receptor for cell entry but maintains broad replicative capability in mammalian cell lines from bats, pigs and humans, indicating that MERS-CoV is different from SARS-CoV [22] . Phylogenetically, however, HCoV-EMC is most closely related to the bat coronaviruses HKU4 and HKU5 in the same Betacoronavirus genus as SARS-CoV, indicating a zoonotic origin
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