Author: Griffiths, Samantha J.; Koegl, Manfred; Boutell, Chris; Zenner, Helen L.; Crump, Colin M.; Pica, Francesca; Gonzalez, Orland; Friedel, Caroline C.; Barry, Gerald; Martin, Kim; Craigon, Marie H.; Chen, Rui; Kaza, Lakshmi N.; Fossum, Even; Fazakerley, John K.; Efstathiou, Stacey; Volpi, Antonio; Zimmer, Ralf; Ghazal, Peter; Haas, Jürgen
Title: A Systematic Analysis of Host Factors Reveals a Med23-Interferon-? Regulatory Axis against Herpes Simplex Virus Type 1 Replication Document date: 2013_8_8
ID: 0lyt8gfq_3
Snippet: To systematically identify host factors (HFs) required for viral replication, RNAi screens have been performed with a range of different RNA and DNA viruses including HIV-1 [7, 8, 9] , Influenza A virus [10, 11, 12] , Hepatitis C virus [13] , West Nile virus [14] , Dengue virus [15] , Enterovirus [16] and Vaccinia virus [17, 18] . The overlap between the results of these studies is generally very low [19] , reflecting either differences in biolog.....
Document: To systematically identify host factors (HFs) required for viral replication, RNAi screens have been performed with a range of different RNA and DNA viruses including HIV-1 [7, 8, 9] , Influenza A virus [10, 11, 12] , Hepatitis C virus [13] , West Nile virus [14] , Dengue virus [15] , Enterovirus [16] and Vaccinia virus [17, 18] . The overlap between the results of these studies is generally very low [19] , reflecting either differences in biology, or different experimental set-ups, cutoff and selection criteria. In addition, microenvironmental effects might also play a role for the differences of the results [20] .
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