Author: Hu, Hao-Teng; Cho, Che-Pei; Lin, Ya-Hui; Chang, Kung-Yao
Title: A general strategy to inhibiting viral -1 frameshifting based on upstream attenuation duplex formation Document date: 2016_1_8
ID: 1u10lpx2_40
Snippet: An alternative approach using complementary PNA to disrupt SARS-CoV −1 PRF stimulator pseudoknot has also achieved antiviral effects and suppressed the propagation of SARS-CoV replicon when tagged with a cellpermeable peptide that facilitates cellular delivery (26) . However, such an approach still requires information on the viral −1 PRF stimulator boundary and may not be deliverable in time. By contrast, the upstream duplex approach provide.....
Document: An alternative approach using complementary PNA to disrupt SARS-CoV −1 PRF stimulator pseudoknot has also achieved antiviral effects and suppressed the propagation of SARS-CoV replicon when tagged with a cellpermeable peptide that facilitates cellular delivery (26) . However, such an approach still requires information on the viral −1 PRF stimulator boundary and may not be deliverable in time. By contrast, the upstream duplex approach provides a more straight-forward means of inhibiting −1 PRF dependent viral pathogens than targeting the viral downstream stimulator and should be applicable as soon as the slippery sequence information of an emerging hCoV is available. Furthermore, the finding of antisense DNAmediated upstream duplex in −1 PRF inhibition in in vitro translation systems should make early stage analysis much more affordable and accessible because expensive modified oligonucleotides are not needed.
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