Selected article for: "cell death and congenital CRS rubella syndrome"
Author: Claus, Claudia; Manssen, Lena; Hübner, Denise; Roßmark, Sarah; Bothe, Viktoria; Petzold, Alice; Große, Claudia; Reins, Mareen; Mankertz, Annette; Frey, Teryl K.; Liebert, Uwe G.
Title: Activation of the Mitochondrial Apoptotic Signaling Platform during Rubella Virus Infection
  • Document date: 2015_11_26
    • ID: 1rrm4sqa_46
    Snippet: The regulation of mPTP composition and function by CypD is still under an ongoing discussion [21] [22] [23] . Overexpression of wild-type (WT) CypD and its PPIase mutants suggests a PPIase-independent involvement of CypD in RV-associated cell death. Hence, in RV-infected Vero cells, its apoptosis regulation and protein-folding functions appear to be separated. This notion also applies to the interaction of CypD with some of its protein partners, .....
    Document: The regulation of mPTP composition and function by CypD is still under an ongoing discussion [21] [22] [23] . Overexpression of wild-type (WT) CypD and its PPIase mutants suggests a PPIase-independent involvement of CypD in RV-associated cell death. Hence, in RV-infected Vero cells, its apoptosis regulation and protein-folding functions appear to be separated. This notion also applies to the interaction of CypD with some of its protein partners, including hexokinase II [35] and the adenine nucleotide translocase (ANT) [36] . Additionally, a modulation of mPTP independent from its enzymatic activity was reported [37] . It was just published that mPTP is a regulatory component of vascular function [38] , which should be viewed in the light of the perturbance of angiogenic processes seen with patients suffering from congenital rubella syndrome (CRS) [39] .

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