Author: Soto-Rodriguez, Guadalupe; Gonzalez-Barrios, Juan-Antonio; Martinez-Fong, Daniel; Blanco-Alvarez, Victor-Manuel; Eguibar, Jose R.; Ugarte, Araceli; Martinez-Perez, Francisco; Brambila, Eduardo; Millán-Perez Peña, Lourdes; Pazos-Salazar, Nidia-Gary; Torres-Soto, Maricela; Garcia-Robles, Guadalupe; Tomas-Sanchez, Constantino; Leon-Chavez, Bertha Alicia
Title: Analysis of Chemokines and Receptors Expression Profile in the Myelin Mutant Taiep Rat Document date: 2015_3_25
ID: 0nb4laxz_15
Snippet: The scatter plots show the expression profile of 84 genes of taiep rat in comparison with the control profile of SD rats (Figure 1 ). No upregulation of proinflammatory cytokines was determined at any age and group studied. In contrast, downregulation was established for IL-1 (−3. Comparisons between results from 6-month-old versus 1month-old rats in the same group show no significant changes in gene expression in SD rats, except for two downre.....
Document: The scatter plots show the expression profile of 84 genes of taiep rat in comparison with the control profile of SD rats (Figure 1 ). No upregulation of proinflammatory cytokines was determined at any age and group studied. In contrast, downregulation was established for IL-1 (−3. Comparisons between results from 6-month-old versus 1month-old rats in the same group show no significant changes in gene expression in SD rats, except for two downregulated chemokines, CXCL9 (−3.9, < 0.05) and TGFB1 (−3.6, < 0.05), while, in taiep rats, gene expression was downregulated for 5 chemokines: CCR8 (−5.2, = 0.05), CCR9 (−7.7, < 0.05), CXCL5 (−2.2, < 0.05), MAPK1 (−15.3, < 0.05), and TGFB1 (−3.5, < 0.05) (Figure 3) .
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