Analysis of Chemokines and Receptors Expression Profile in the Myelin Mutant Taiep Rat

Soto-Rodriguez, Guadalupe; Gonzalez-Barrios, Juan-Antonio; Martinez-Fong, Daniel; Blanco-Alvarez, Victor-Manuel; Eguibar, Jose R.; Ugarte, Araceli; Martinez-Perez, Francisco; Brambila, Eduardo; Millán-Perez Peña, Lourdes; Pazos-Salazar, Nidia-Gary; Torres-Soto, Maricela; Garcia-Robles, Guadalupe; Tomas-Sanchez, Constantino; Leon-Chavez, Bertha Alicia

Comparison of protein levels between taiep rats and SD rats showed changes in chemokine receptors and growth factors at both ages. At 1 month of age, receptors that increased were CCR2 (43.5 ± 5.1%), CCR8 (111.3 ± 12.4%), CXCR4 (115.8 ± 18.1%), and FGF2 (27.6% ± 4.1). In contrast, CCR5 (−19.8 ± 5.1) and CXCL1 (−82.2 ± 1.6%) were decreased (Figure 4 ). In the brainstem of 6-month-old rats, protein levels were decreased for CCL2 (−39.0% ± 5.5%), CXCL1 (−80.9% ± 3.6%), CCR1 (−14.4% ± 7.9%), CCR2 (−41.2% ± 1.4%), CCR5 (−21.8% ± 5.8%), CCR8 (−34.6% ± 5.8%), CXCR4 (−54.4% ± 3.7%), and, the growth factor, FGF2 (−42.7% ± 2.7%). In contrast, VEGFA (125.5% ± 29.7%) levels increased (Figure 4) .