Selected article for: "old taiep and OPCs migration"
Author: Soto-Rodriguez, Guadalupe; Gonzalez-Barrios, Juan-Antonio; Martinez-Fong, Daniel; Blanco-Alvarez, Victor-Manuel; Eguibar, Jose R.; Ugarte, Araceli; Martinez-Perez, Francisco; Brambila, Eduardo; Millán-Perez Peña, Lourdes; Pazos-Salazar, Nidia-Gary; Torres-Soto, Maricela; Garcia-Robles, Guadalupe; Tomas-Sanchez, Constantino; Leon-Chavez, Bertha Alicia
Title: Analysis of Chemokines and Receptors Expression Profile in the Myelin Mutant Taiep Rat
  • Document date: 2015_3_25
    • ID: 0nb4laxz_25
    Snippet: We found that VEGF mRNA and protein levels are increased in 6-month-old taiep rats. This factor released by astrocytes is known to disrupt the blood-brain barrier in CNS inflammatory disease [48] . In addition, VEGF promotes OPC migration to the myelination areas [49] . However, OPC migration is altered in taiep rats [7, 8] despite the increased VEGF levels. The alteration of OPC migration might be explained by the deficiency of CXL1 and CXCR4 fo.....
    Document: We found that VEGF mRNA and protein levels are increased in 6-month-old taiep rats. This factor released by astrocytes is known to disrupt the blood-brain barrier in CNS inflammatory disease [48] . In addition, VEGF promotes OPC migration to the myelination areas [49] . However, OPC migration is altered in taiep rats [7, 8] despite the increased VEGF levels. The alteration of OPC migration might be explained by the deficiency of CXL1 and CXCR4 found here. The role of VEGF in OPCs migration was proven by blocking VEGF receptor with anti-Flk-1 antibody [49] . Finally, the increased levels of VEGF, CXCL10, and CCL19 might account for the infiltration of lymphocytes CD4+ and CD8+ previously found in the taiep rats at the age of 6 months.

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