Selected article for: "bacterial infection and COPD bacterial infection"
Author: Aran Singanayagam; Su-Ling Loo; Maria Calderazzo; Lydia J Finney; Maria-Belen Trujillo Torralbo; Eteri Bakhsoliani; Jason Girkin; Punnam Veerati; Prabuddha S Pathinayake; Kristy S Nichol; Andrew Reid; Joseph Foottit; Sebastian L Johnston; Nathan W Bartlett; Patrick Mallia
Title: Anti-microbial immunity is impaired in COPD patients with frequent exacerbations
  • Document date: 2019_5_9
    • ID: 72jzqm86_36
    Snippet: We next focused on other another AMP that could be important in driving secondary bacterial infection in COPD. A previous study reported that mannose-binding lectin (MBL)-2 polymorphisms with associated MBL-2 deficiency in serum is associated with recurrence of infective exacerbations in COPD 25 . Consistent with this report, we also found that MBL-2 concentrations in sputum were significantly reduced in frequent versus infrequent exacerbators at.....
    Document: We next focused on other another AMP that could be important in driving secondary bacterial infection in COPD. A previous study reported that mannose-binding lectin (MBL)-2 polymorphisms with associated MBL-2 deficiency in serum is associated with recurrence of infective exacerbations in COPD 25 . Consistent with this report, we also found that MBL-2 concentrations in sputum were significantly reduced in frequent versus infrequent exacerbators at stable state ( Figure 5a ) and also at 2 weeks post exacerbation onset (Figure 5b) , the same timepoint at which bacterial loads were increased.

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