Author: Aran Singanayagam; Su-Ling Loo; Maria Calderazzo; Lydia J Finney; Maria-Belen Trujillo Torralbo; Eteri Bakhsoliani; Jason Girkin; Punnam Veerati; Prabuddha S Pathinayake; Kristy S Nichol; Andrew Reid; Joseph Foottit; Sebastian L Johnston; Nathan W Bartlett; Patrick Mallia
Title: Anti-microbial immunity is impaired in COPD patients with frequent exacerbations Document date: 2019_5_9
ID: 72jzqm86_47
Snippet: It is plausible that patients with frequent exacerbations might represent one sub-group with impaired anti-viral immunity. We report here that expression of both type I and type III IFNs, IFNβ and IFNλ2/3 mRNAs is reduced in frequent exacerbators at stable state, suggesting that these patients might have a reduced potential to generate protective responses to virus infection. In support of this hypothesis, we also observed that anti-viral respo.....
Document: It is plausible that patients with frequent exacerbations might represent one sub-group with impaired anti-viral immunity. We report here that expression of both type I and type III IFNs, IFNβ and IFNλ2/3 mRNAs is reduced in frequent exacerbators at stable state, suggesting that these patients might have a reduced potential to generate protective responses to virus infection. In support of this hypothesis, we also observed that anti-viral responses including IFNβ, IFNλ1 and IFNλ2/3 and the ISGs 2'-5'OAS author/funder. All rights reserved. No reuse allowed without permission.
Search related documents:
Co phrase search for related documents- anti viral immunity and iii ifn: 1
- anti viral immunity and impaired anti viral immunity: 1, 2, 3, 4, 5
- anti viral immunity and protective response: 1
- anti viral immunity and stable state: 1, 2
- anti viral response and hypothesis support: 1, 2
- anti viral response and iii ifn: 1, 2
- anti viral response and protective response: 1
- frequent exacerbator and stable state: 1
- hypothesis support and iii ifn: 1
- hypothesis support and protective response: 1, 2
- hypothesis support and reduce potential: 1
- IFNβ iii ifn and iii ifn: 1, 2, 3, 4, 5
- IFNβ iii ifn type and iii ifn: 1, 2, 3, 4
- protective response and stable state: 1
- reduce potential and stable state: 1
Co phrase search for related documents, hyperlinks ordered by date