Author: Jones, Harrison G.; Battles, Michael B.; Lin, Chun-Chi; Bianchi, Siro; Corti, Davide; McLellan, Jason S.
Title: Alternative conformations of a major antigenic site on RSV F Document date: 2019_7_15
ID: 1r20hl2b_11
Snippet: To investigate the conformation of site Ø and define the epitope on prefusion RSV F recognized by AM22, we determined the crystal structure of the AM22 Fab alone and in complex with the prefusion-stabilized RSV F variant DS-Cav1 [40] . Crystals of the AM22 Fab alone diffracted X-rays to 1.7 Å and crystals of the prefusion RSV F-AM22 complex diffracted X-rays to 3.5 Å ( Table 1 ). The AM22 variable domain (Fv) superimposes very well between the.....
Document: To investigate the conformation of site Ø and define the epitope on prefusion RSV F recognized by AM22, we determined the crystal structure of the AM22 Fab alone and in complex with the prefusion-stabilized RSV F variant DS-Cav1 [40] . Crystals of the AM22 Fab alone diffracted X-rays to 1.7 Å and crystals of the prefusion RSV F-AM22 complex diffracted X-rays to 3.5 Å ( Table 1 ). The AM22 variable domain (Fv) superimposes very well between the bound and unbound crystal structures, with high structural similarity across the framework and complementarity-determining regions (CDRs) resulting in an r.m.s.d. of~0.31 Å for 214 Cα atoms.
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