Author: Saeed, Abdullah F. U. H.; Wang, Rongzhi; Ling, Sumei; Wang, Shihua
Title: Antibody Engineering for Pursuing a Healthier Future Document date: 2017_3_28
ID: 0fegsm1v_171
Snippet: Therapeutic antibodies have been generated to fight off several infectious cancers. Cancer is a group of diseases that involve abnormal cell growth and proliferation caused by alterations, or mutations, in the genetic material of the cells. The cell outgrowths or lumps may be benign or metastatic (Marusyk and Polyak, 2010) . Cancer outpaces the immune system, avoids detection, or blocks immune system activity. Thus, numerous therapeutic antibodie.....
Document: Therapeutic antibodies have been generated to fight off several infectious cancers. Cancer is a group of diseases that involve abnormal cell growth and proliferation caused by alterations, or mutations, in the genetic material of the cells. The cell outgrowths or lumps may be benign or metastatic (Marusyk and Polyak, 2010) . Cancer outpaces the immune system, avoids detection, or blocks immune system activity. Thus, numerous therapeutic antibodies such as necitumumab, ramucirumab, GRN1005, ganitumab, cixutumumab MM-121, BIIB 033, mapatumumab, trebananib, BHQ880, and carlumab have been investigated for the successful treatment of human cancers. The malignancies include NSCLC, metastatic gastric adenocarcinoma, brain metastasis, breast, ovarian, peritoneal, fallopian tube, prostate, pancreatic, and colorectal cancers, melanoma of the eye and liver, non-Hodgkin lymphoma, and multiple myeloma (Dantas-Barbosa et al., 2012; Nixon et al., 2014) .
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