Analysis of Chemokines and Receptors Expression Profile in the Myelin Mutant Taiep Rat

Soto-Rodriguez, Guadalupe; Gonzalez-Barrios, Juan-Antonio; Martinez-Fong, Daniel; Blanco-Alvarez, Victor-Manuel; Eguibar, Jose R.; Ugarte, Araceli; Martinez-Perez, Francisco; Brambila, Eduardo; Millán-Perez Peña, Lourdes; Pazos-Salazar, Nidia-Gary; Torres-Soto, Maricela; Garcia-Robles, Guadalupe; Tomas-Sanchez, Constantino; Leon-Chavez, Bertha Alicia

The deficiency of the CXCL1 and CXCR4 proteins in the taiep rats might affect the proliferative response and recruitment of OPC to the injured areas [21, 38] . Lack of CXCL1 may also contribute to differentiation failure of OPCs [39, 40] . Altogether, these alterations of OPCs limit the remyelination in the taiep rats. On the contrary, the increased CXCL1 mRNA and protein levels in other myelin mutants such as jimpy mice were associated with a remyelination process in the spinal cord [41] . However, CXCL1 mRNA was not affected in the taiep rats; the decrease of CXCL1 protein levels could be explained by instability of mRNA or a failure in its regulation. Related to the former suggestion, it has been reported that CXCL1 mRNAs contain adenine-uridine-rich sequence elements (AREs) in their 3 -untranslated regions (3 -UTRs) that exhibit constitutive instability. These regions are stabilized by acute proinflammatory stimulus, that is, IL-17 [42] [43] [44] , that is not present in the taiep rats.