Author: Griffiths, Samantha J.; Koegl, Manfred; Boutell, Chris; Zenner, Helen L.; Crump, Colin M.; Pica, Francesca; Gonzalez, Orland; Friedel, Caroline C.; Barry, Gerald; Martin, Kim; Craigon, Marie H.; Chen, Rui; Kaza, Lakshmi N.; Fossum, Even; Fazakerley, John K.; Efstathiou, Stacey; Volpi, Antonio; Zimmer, Ralf; Ghazal, Peter; Haas, Jürgen
Title: A Systematic Analysis of Host Factors Reveals a Med23-Interferon-? Regulatory Axis against Herpes Simplex Virus Type 1 Replication Document date: 2013_8_8
ID: 0lyt8gfq_12
Snippet: Analysis of this interactome for HFs identified by RNAi found they were enriched in the fraction of cellular proteins that directly interact with viral proteins or that interact via one intermediate, in comparison to proteins that only interact via 2 or more intermediates (p = 0.036, Fisher's exact test)( Figure S1f) . A direct comparison of HSV-1 protein interaction partners and the siRNA screen HFs found 215 genes in common. Of those, ten (4.6%.....
Document: Analysis of this interactome for HFs identified by RNAi found they were enriched in the fraction of cellular proteins that directly interact with viral proteins or that interact via one intermediate, in comparison to proteins that only interact via 2 or more intermediates (p = 0.036, Fisher's exact test)( Figure S1f) . A direct comparison of HSV-1 protein interaction partners and the siRNA screen HFs found 215 genes in common. Of those, ten (4.6%) were identified as a hit in both screens ( Table S4 in Text S2), suggesting that these technologies identify complimentary yet not necessarily overlapping HFs.
Search related documents:
Co phrase search for related documents- cellular protein and Fisher exact test: 1
- cellular protein and interaction partner: 1, 2, 3, 4
- cellular protein and protein comparison: 1, 2, 3, 4, 5
- cellular protein and protein interaction partner: 1, 2
- cellular protein and RNAi identify: 1
- cellular protein and viral protein: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76
- cellular protein and viral protein interact: 1, 2, 3
- direct comparison and exact test: 1, 2
- direct comparison and protein comparison: 1
- directly viral protein interact and viral protein: 1, 2
- directly viral protein interact and viral protein interact: 1, 2
- exact test and Fisher exact test: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76
- exact test and viral protein: 1
- Fisher exact test and viral protein: 1
- interaction partner and protein interaction partner: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
- interaction partner and viral protein: 1, 2, 3, 4, 5, 6, 7
- interaction partner and viral protein interact: 1
- intermediate interact and viral protein: 1
- protein comparison and viral protein: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16
Co phrase search for related documents, hyperlinks ordered by date