Author: Claus, Claudia; Manssen, Lena; Hübner, Denise; Roßmark, Sarah; Bothe, Viktoria; Petzold, Alice; Große, Claudia; Reins, Mareen; Mankertz, Annette; Frey, Teryl K.; Liebert, Uwe G.
Title: Activation of the Mitochondrial Apoptotic Signaling Platform during Rubella Virus Infection Document date: 2015_11_26
ID: 1rrm4sqa_40
Snippet: Mitochondria are crucial in the execution of programmed cell death and therefore an important line of defense against various insults such as pathogenic infections. Hence some proteins of important human pathogenic viruses do even localize within mitochondria to interfere with apoptosis [26] . Another important cellular factor for viral countermeasures against cellular defense mechanisms is the tumor-suppressor protein p53 as an important orchest.....
Document: Mitochondria are crucial in the execution of programmed cell death and therefore an important line of defense against various insults such as pathogenic infections. Hence some proteins of important human pathogenic viruses do even localize within mitochondria to interfere with apoptosis [26] . Another important cellular factor for viral countermeasures against cellular defense mechanisms is the tumor-suppressor protein p53 as an important orchestrator of those intertwined and interdependent mitochondrial functions [27] . The data presented in this paper indicate that RV-induced apoptosis as well as its cell-culture adaptation involve a balance between nuclear and extranuclear functions of p53. Additionally, RV induces release of pro-apoptotic proteins from mitochondria and nuclear translocation of Cyp40. The presented data are summarized in Figure 9 as a proposed model for the mitochondria-and p53-associated pathways during RV-induced apoptosis.
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