Antibody Engineering for Pursuing a Healthier Future

Saeed, Abdullah F. U. H.; Wang, Rongzhi; Ling, Sumei; Wang, Shihua

Similarly, an essential factor of NPs selection is that nanometer-sized (colloidal gold or silver) particles can be conjugated with targeting ligands, including mAbs, peptides, or small molecules with functional and structural properties that are not available from either discrete molecules or bulk materials. Nanoparticles are probed with mAbs that can be used to target any antigen of interest (Ling et al., 2015a) . The use of colloidal gold is a rapid, less time consuming, and cost effective technique. This technology has been used in the development of immunochromatic strip assays based on mAb. The technique has widespread applications for the detection of a number of antigens (exogenous antigens, endogenous antigens, autoantigens, neoantigens, viral antigens, and tumor antigens) with high specificity and binding affinity (Schumacher and Schreiber, 2015) .