Selected article for: "constant region and variable region"
Author: Saeed, Abdullah F. U. H.; Wang, Rongzhi; Ling, Sumei; Wang, Shihua
Title: Antibody Engineering for Pursuing a Healthier Future
  • Document date: 2017_3_28
    • ID: 0fegsm1v_2
    Snippet: Antibodies consist of two heavy chains [variable (V H ), joining (J H ), diversity (D), and constant (C) region] and two light chains [variable (V H ), joining (J H ), and constant (C) region], that are linked by non-covalent bonding and disulfide (s-s) bridges (Hamers-Casterman et al., 1993) . Antibodies bind antigen with the help of a VHH fragment that can identify specific and unique conformational epitopes by the presence of its long compleme.....
    Document: Antibodies consist of two heavy chains [variable (V H ), joining (J H ), diversity (D), and constant (C) region] and two light chains [variable (V H ), joining (J H ), and constant (C) region], that are linked by non-covalent bonding and disulfide (s-s) bridges (Hamers-Casterman et al., 1993) . Antibodies bind antigen with the help of a VHH fragment that can identify specific and unique conformational epitopes by the presence of its long complementary determining regions (CDR3). Escherichia coli expression systems are unique for the validation of the correct functioning of antibody fragments in the periplasmic space or cytoplasm. Conversely, periplasmic expression systems help V H and V L pairing by providing optimal conditions to allow the production of functional molecules (Sonoda et al., 2011) .

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