Author: Saeed, Abdullah F. U. H.; Wang, Rongzhi; Ling, Sumei; Wang, Shihua
Title: Antibody Engineering for Pursuing a Healthier Future Document date: 2017_3_28
ID: 0fegsm1v_163
Snippet: B and T cell epitope conformation is determined by pepscan technique, which has led to the development of antibody therapeutics, vaccine design, and recognition of protective antibody responses (Ahmad et al., 2016) . The technique also targets pathogens with novel antimicrobials. Examples include the V-shaped Ab52 glycan epitope in the O-antigen of Francisella tularensis, the CR6261 peptidic epitope in influenza virus H1N1, and the PG16 glycopept.....
Document: B and T cell epitope conformation is determined by pepscan technique, which has led to the development of antibody therapeutics, vaccine design, and recognition of protective antibody responses (Ahmad et al., 2016) . The technique also targets pathogens with novel antimicrobials. Examples include the V-shaped Ab52 glycan epitope in the O-antigen of Francisella tularensis, the CR6261 peptidic epitope in influenza virus H1N1, and the PG16 glycopeptidic epitope in the gp120 V1/V2 loop of HIV type 1 (Sharon et al., 2014) . Peptides are screened by biopanning with antibodies from the sera of various human diseases, including severe acute respiratory syndrome (SARS), human papillomavirus (HPV), and avian influenza viruses (AIV). Moreover, peptide-based antigens are also used for serological diagnosis and development of vaccines .
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