Author: Jones, Harrison G.; Battles, Michael B.; Lin, Chun-Chi; Bianchi, Siro; Corti, Davide; McLellan, Jason S.
Title: Alternative conformations of a major antigenic site on RSV F Document date: 2019_7_15
ID: 1r20hl2b_12
Snippet: The crystal structure of the F-AM22 complex shows that three AM22 Fabs bind to prefusion RSV F at the membrane-distal apex of the trimer and have a vertical angle of approach (Fig 2A) , in agreement with previously published negative stain EM images [8] . AM22 buries 729 Ã… 2 of surface area on each protomer of prefusion RSV F, mediated primarily through interactions between the heavy chain and F1 subunit......
Document: The crystal structure of the F-AM22 complex shows that three AM22 Fabs bind to prefusion RSV F at the membrane-distal apex of the trimer and have a vertical angle of approach (Fig 2A) , in agreement with previously published negative stain EM images [8] . AM22 buries 729 Ã… 2 of surface area on each protomer of prefusion RSV F, mediated primarily through interactions between the heavy chain and F1 subunit.
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