Author: Jones, Harrison G.; Battles, Michael B.; Lin, Chun-Chi; Bianchi, Siro; Corti, Davide; McLellan, Jason S.
Title: Alternative conformations of a major antigenic site on RSV F Document date: 2019_7_15
ID: 1r20hl2b_23
Snippet: The structural studies presented here reveal alternative conformations of RSV F site Ø in the prefusion state and suggest a natural flexibility of the region that can be recognized in numerous ways by the humoral immune system. This conformational flexibility is further supported by crystal structures of multiple prefusion-stabilized variants, which have identified an array of site Ø conformations, very high atomic B factors, or a distinct lack.....
Document: The structural studies presented here reveal alternative conformations of RSV F site Ø in the prefusion state and suggest a natural flexibility of the region that can be recognized in numerous ways by the humoral immune system. This conformational flexibility is further supported by crystal structures of multiple prefusion-stabilized variants, which have identified an array of site Ø conformations, very high atomic B factors, or a distinct lack of site Ø electron density (PDB IDs: 4JHW, 4MMQ-4MMV, 4ZYP, 5C69, 5C6B, 5EA3-5EA8, 5KWW, 5K6B, and pink. (B) Close-up of the side views of the interactions between one RSD5-GL Fab and one RSV F protomer in ribbon-and-stick representation, rotated 180˚from each other and colored as in (A). For stick models, oxygen atoms are colored red, nitrogen blue, and sulfur yellow. (C) Ribbon-and-stick model of the RSD5-GL CDR loops contacting one protomer of RSV F, which is shown as a molecular surface. Colored as in (B) and rotated as indicated. (D) The amino acid sequence of residues near RSV F site Ø and site V are shown for both strain A2 and strain B9320. Diamond symbols above each residue indicate a contact between RSD5-GL and prefusion RSV F strain A2 based upon PDBePISA analysis of the crystal structure.
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