Author: Jones, Harrison G.; Battles, Michael B.; Lin, Chun-Chi; Bianchi, Siro; Corti, Davide; McLellan, Jason S.
Title: Alternative conformations of a major antigenic site on RSV F Document date: 2019_7_15
ID: 1r20hl2b_28
Snippet: Recent characterization of the antibody repertoire against RSV F highlights the importance of prefusion-specific epitopes when selecting immunogens for RSV F vaccine design, particularly after the recent failure of several postfusion RSV F vaccine trials [16, 18, 32, 33, 61, 62] . Our findings demonstrate that potently neutralizing human antibodies that target antigenic site Ø can recognize a variety of alternative conformations and have varying.....
Document: Recent characterization of the antibody repertoire against RSV F highlights the importance of prefusion-specific epitopes when selecting immunogens for RSV F vaccine design, particularly after the recent failure of several postfusion RSV F vaccine trials [16, 18, 32, 33, 61, 62] . Our findings demonstrate that potently neutralizing human antibodies that target antigenic site Ø can recognize a variety of alternative conformations and have varying degrees of subtype specificity. Because potent antibodies can bind to the various alternative conformations of site Ø, we propose that the ideal prefusion RSV F immunogen would maintain this natural conformational flexibility of site Ø as well as present neutralizing epitopes common to both RSV subtypes.
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