Author: Claus, Claudia; Manssen, Lena; Hübner, Denise; Roßmark, Sarah; Bothe, Viktoria; Petzold, Alice; Große, Claudia; Reins, Mareen; Mankertz, Annette; Frey, Teryl K.; Liebert, Uwe G.
Title: Activation of the Mitochondrial Apoptotic Signaling Platform during Rubella Virus Infection Document date: 2015_11_26
ID: 1rrm4sqa_43
Snippet: Through the application of PFTµ, this paper indicates that p53-based pathways are involved in programmed cell death mechanisms induced by RV infection. In comparison to the Therien and HPV77 strains, the clinical isolate Wb-12 induced a stronger signal of nuclear p53. This suggests that during cell-culture adaptation RV strains have evolved mechanisms to counteract or to avoid nuclear localization of p53. The application of PFTµ appears to supp.....
Document: Through the application of PFTµ, this paper indicates that p53-based pathways are involved in programmed cell death mechanisms induced by RV infection. In comparison to the Therien and HPV77 strains, the clinical isolate Wb-12 induced a stronger signal of nuclear p53. This suggests that during cell-culture adaptation RV strains have evolved mechanisms to counteract or to avoid nuclear localization of p53. The application of PFTµ appears to support the previously published anti-apoptotic activity of Therien, which is also reflected by the association of its C protein with Bax [7] . The present paper ties in with this reported involvement of a mitochondrial signaling pathway in RV-infected A549 cells and subsequently viral strategies to counteract cellular death mechanisms. Additionally, application of PFTµ to RV-infected Vero cells increases p53 nuclear expression during RV infection, highlighting that blocking one branch of p53 activity favors the other. However, Therien appears not to be affected by the PFTµ-associated increase in nuclear p53 localization, as PFTµ reduces CPE.
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