Author: Criscuolo, E.; Caputo, V.; Diotti, R. A.; Sautto, G. A.; Kirchenbaum, G. A.; Clementi, N.
Title: Alternative Methods of Vaccine Delivery: An Overview of Edible and Intradermal Vaccines Document date: 2019_3_4
ID: 0xo2fiop_4
Snippet: 1.1. The Mucosal Delivery and the Immune Response. The efficacy of the mucosal administration route is largely based on the fact that mucous membranes constitute the largest immunologic organ in the body. Moreover, this interface is endowed with well-organized lymphatic structures, termed mucosa-associated lymphoid tissue (MALT), containing both the innate and adaptive (T and B cells) arms of the immune system [9] . Furthermore, antigen-specific .....
Document: 1.1. The Mucosal Delivery and the Immune Response. The efficacy of the mucosal administration route is largely based on the fact that mucous membranes constitute the largest immunologic organ in the body. Moreover, this interface is endowed with well-organized lymphatic structures, termed mucosa-associated lymphoid tissue (MALT), containing both the innate and adaptive (T and B cells) arms of the immune system [9] . Furthermore, antigen-specific SIgA plays a pivotal role in protecting mucosal surfaces from both microbe adhesion and toxin activities [8] . Thus, the development of novel vaccine delivery platforms implementing the elicitation of pathogen-or toxin-specific SIgA, as well as systemic IgG, is pivotal to improve vaccine effectiveness [10] .
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