Antibody Engineering for Pursuing a Healthier Future

Saeed, Abdullah F. U. H.; Wang, Rongzhi; Ling, Sumei; Wang, Shihua

Human immune libraries developed by PDT facilitate the study of autoimmune and neurological disorder physiology, clinical diagnostics, and the treatment of AITP (platelet disorder caused by anti-platelet autoantibodies), MS, myasthenia gravis (MG) [antibodies against nicotinic acetylcholine receptor (AcChoR)], thrombotic thrombocytopenic purpura (TTP), Cogan's syndrome (CS) caused by systemic vasculitis, acute anterior uveitis (AAU), ocular inflammation, insulin dependent diabetes mellitus (IDDM) caused by the destruction of pancreatic beta cells, Wegener's granulomatosis (Finnern et al., 1997) , autoimmune thyroid disease (Latrofa et al., 2003) , primary biliary cirrhosis (PBC), and Sjögren's syndrome (SS). Additionally, the technique has therapeutic uses in blistering skin diseases, pemphigus vulgaris (PV) (Payne et al., 2005) , pemphigus foliaceus (PF) (Ishii et al., 2008) , autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC), mixed cryoglobulinemia (CryoII), systemic sclerosis (SSc), autoimmune cholangitis (AIC), antiphospholipid syndrome (APS), vitiligo rheumatoid arthritis, Crohn's disease, Graves' disease (GD), and celiac disease (genetic inflammatory disorder) (Zohreh and Hossein, 2008) .