Author: Claus, Claudia; Manssen, Lena; Hübner, Denise; Roßmark, Sarah; Bothe, Viktoria; Petzold, Alice; Große, Claudia; Reins, Mareen; Mankertz, Annette; Frey, Teryl K.; Liebert, Uwe G.
Title: Activation of the Mitochondrial Apoptotic Signaling Platform during Rubella Virus Infection Document date: 2015_11_26
ID: 1rrm4sqa_67
Snippet: There are conflicting reports on the mode of rubella virus (RV)-associated cell death and on possible differences between viral strains. Through application of selected pharmacological inhibitors, the present study highlights the contribution of mitochondria-and p53-centered apoptotic pathways to cytopathic effect induction by RV. Additionally, the relevance of the so far not well-characterized Cyp40 protein in the cellular stress response was em.....
Document: There are conflicting reports on the mode of rubella virus (RV)-associated cell death and on possible differences between viral strains. Through application of selected pharmacological inhibitors, the present study highlights the contribution of mitochondria-and p53-centered apoptotic pathways to cytopathic effect induction by RV. Additionally, the relevance of the so far not well-characterized Cyp40 protein in the cellular stress response was emphasized. Our present work also shows that p53 may contribute to differences among RV cell culture-adapted strains and a low-passaged clinical isolate.
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