Author: Claus, Claudia; Manssen, Lena; Hübner, Denise; Roßmark, Sarah; Bothe, Viktoria; Petzold, Alice; Große, Claudia; Reins, Mareen; Mankertz, Annette; Frey, Teryl K.; Liebert, Uwe G.
Title: Activation of the Mitochondrial Apoptotic Signaling Platform during Rubella Virus Infection Document date: 2015_11_26
ID: 1rrm4sqa_67
Snippet: There are conflicting reports on the mode of rubella virus (RV)-associated cell death and on possible differences between viral strains. Through application of selected pharmacological inhibitors, the present study highlights the contribution of mitochondria-and p53-centered apoptotic pathways to cytopathic effect induction by RV. Additionally, the relevance of the so far not well-characterized Cyp40 protein in the cellular stress response was em.....
Document: There are conflicting reports on the mode of rubella virus (RV)-associated cell death and on possible differences between viral strains. Through application of selected pharmacological inhibitors, the present study highlights the contribution of mitochondria-and p53-centered apoptotic pathways to cytopathic effect induction by RV. Additionally, the relevance of the so far not well-characterized Cyp40 protein in the cellular stress response was emphasized. Our present work also shows that p53 may contribute to differences among RV cell culture-adapted strains and a low-passaged clinical isolate.
Search related documents:
Co phrase search for related documents- apoptotic pathway and cell death: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- apoptotic pathway and present study: 1, 2, 3, 4, 5, 6, 7
- apoptotic pathway and present work: 1
- cell culture and clinical isolate: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23
- cell culture and effect induction: 1, 2, 3
- cell culture and low passaged clinical isolate: 1, 2
- cell culture and possible difference: 1
- cell culture and present study: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- cell culture and present work: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- cell culture and rubella virus: 1, 2, 3, 4
- cell death and clinical isolate: 1, 2
- cell death and effect induction: 1, 2, 3, 4, 5, 6
- cell death and pharmacological inhibitor: 1, 2
- cell death and present study: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- cell death and present work: 1, 2, 3, 4, 5, 6, 7, 8, 9
- cell death and rubella virus: 1, 2
- cellular stress response and present study: 1, 2, 3, 4, 5, 6
- clinical isolate and present work: 1
- clinical isolate and rubella virus: 1, 2
Co phrase search for related documents, hyperlinks ordered by date