Selected article for: "immune response and virus replication"
Author: Buonaguro, Franco Maria; Puzanov, Igor; Ascierto, Paolo Antonio
Title: Anti-IL6R role in treatment of COVID-19-related ARDS
  • Document date: 2020_4_14
    • ID: 0pigqtzt_11
    Snippet: Until that time, it seems plausible to speculate that the anti-IL6R mAb plays a protective role if given at the time of overly elevated immune response to the virus, thus preventing "anaphylactic toxicity". Such extreme cytokine reaction is accompanied by infiltration of inflammatory monocytes/macrophages (IMM) into the lung and elevated production of the pro-inflammatory cytokines (IL-1, IL-6, IL-8, CXCL-10, and MCP-1). These events are associat.....
    Document: Until that time, it seems plausible to speculate that the anti-IL6R mAb plays a protective role if given at the time of overly elevated immune response to the virus, thus preventing "anaphylactic toxicity". Such extreme cytokine reaction is accompanied by infiltration of inflammatory monocytes/macrophages (IMM) into the lung and elevated production of the pro-inflammatory cytokines (IL-1, IL-6, IL-8, CXCL-10, and MCP-1). These events are associated with severe lung damage, characterized by profound vascular leakage, and death [7] . In this context the anti-IL6R may only be controlling the "cytokine storm" without deleterious effect on virus replication.

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