Selected article for: "cascade signal and signal cascade"
Author: Wang, Kai; Ran, Ling; Yan, Tao; Niu, Zheng; Kan, Zifei; Zhang, Yiling; Yang, Yang; Xie, Luyi; Huang, Shilei; Yu, Qiuhan; Wu, Di; Song, Zhenhui
Title: Anti-TGEV Miller Strain Infection Effect of Lactobacillus plantarum Supernatant Based on the JAK-STAT1 Signaling Pathway
  • Document date: 2019_11_6
    • ID: 05tf6oqa_2
    Snippet: The body reacts rapidly to viral invasion by synthesizing and secreting type I interferon IFN-1 (IFN-α/β), which plays a key role in the host antiviral response. The binding of IFN-1 to its receptor (interferon α/β receptor, IFNAR) leads to activation of the Janus family kinase (JAK) and subsequent signal transduction and transcriptional activator (STAT) signaling cascade, resulting in the activation and upregulation of interferon-stimulating.....
    Document: The body reacts rapidly to viral invasion by synthesizing and secreting type I interferon IFN-1 (IFN-α/β), which plays a key role in the host antiviral response. The binding of IFN-1 to its receptor (interferon α/β receptor, IFNAR) leads to activation of the Janus family kinase (JAK) and subsequent signal transduction and transcriptional activator (STAT) signaling cascade, resulting in the activation and upregulation of interferon-stimulating genes (ISGs), ultimately activating IFN to exert its antiviral effects (Zhao et al., 2016; Chen et al., 2017) .

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