Author: Zhai, Xiaofeng; Wang, Shilei; Zhu, Mengyan; He, Wei; Pan, Zhongzhou; Su, Shuo
Title: Antiviral Effect of Lithium Chloride and Diammonium Glycyrrhizinate on Porcine Deltacoronavirus In Vitro Document date: 2019_9_9
ID: 1m5yr8uc_24
Snippet: LiCl and DG have no viricidal effect on PDCoV virions. To understand whether LiCl and DG have a direct (viricidal) effect on virions, we incubated PDCoV (MOI 0.05) with 60 mM LiCl or 1250 µg/mL DG for 2 h at room temperature or 37 • C before infection of LLC-PK1 cells. The infectious titer was determined by TCID 50 at 48 hours postinfection (hpi). We found that none of the drugs directly inhibited PDCoV infectivity ( Figure 5A,B) ......
Document: LiCl and DG have no viricidal effect on PDCoV virions. To understand whether LiCl and DG have a direct (viricidal) effect on virions, we incubated PDCoV (MOI 0.05) with 60 mM LiCl or 1250 µg/mL DG for 2 h at room temperature or 37 • C before infection of LLC-PK1 cells. The infectious titer was determined by TCID 50 at 48 hours postinfection (hpi). We found that none of the drugs directly inhibited PDCoV infectivity ( Figure 5A,B) .
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