Selected article for: "human apod and liver plasma"
Author: Labrie, Marilyne; Lalonde, Simon; Najyb, Ouafa; Thiery, Maxime; Daneault, Caroline; Des Rosiers, Chrisitne; Rassart, Eric; Mounier, Catherine
Title: Apolipoprotein D Transgenic Mice Develop Hepatic Steatosis through Activation of PPAR? and Fatty Acid Uptake
  • Document date: 2015_6_17
    • ID: 0wtq1c15_1
    Snippet: Apolipoprotein D (apoD), a 29 kDa glycoprotein, is a member of the lipocalin super family [1] . It transports several small hydrophobic compounds such as arachidonic acid (AA), progesterone, pregnenolone, bilirubin, cholesterol and E-3-methyl-2-hexenoic acid [2] [3] [4] [5] [6] [7] . In human, apoD is found in the plasma fraction, associated with high-density lipoprotein (HDL). It is mice is the result of PPARγ activation by AA, one of the main .....
    Document: Apolipoprotein D (apoD), a 29 kDa glycoprotein, is a member of the lipocalin super family [1] . It transports several small hydrophobic compounds such as arachidonic acid (AA), progesterone, pregnenolone, bilirubin, cholesterol and E-3-methyl-2-hexenoic acid [2] [3] [4] [5] [6] [7] . In human, apoD is found in the plasma fraction, associated with high-density lipoprotein (HDL). It is mice is the result of PPARγ activation by AA, one of the main ligand of apoD. Supporting this hypothesis, we showed that AA concentration is enriched in liver and decreased in plasma. Our work reveals a novel mechanism of apoD action in lipid metabolism.

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