Selected article for: "control group and negative control group"
Author: Shenglan Shang; Jiaqi Wu; Xiaoli Li; Xin Liu; Pan Li; Chunli Zheng; Yonghua Wang; Songqing Liu; Jiang Zheng; Hong Zhou
Title: Artesunate interacts with Vitamin D receptor to reverse mouse model of sepsis-induced immunosuppression via enhancing autophagy
  • Document date: 2020_2_27
    • ID: egntml7e_67
    Snippet: Autophagy is an important self-protection mechanism required for bacterial clearance and inflammation (Gutierrez, Master, Singh, Taylor, Colombo & Deretic, 2004; Levine, Mizushima & Virgin, 2011) . ATG16L1, the target gene of VDR and a regulator for autophagy, links VDR and autophagy (Wu & Sun, 2011) . Firstly, to confirm the function of ATG16L1, cells were treated with ATG16L1 siRNA ( Figure S3a ). The results showed that TNF-α and IL-6 levels .....
    Document: Autophagy is an important self-protection mechanism required for bacterial clearance and inflammation (Gutierrez, Master, Singh, Taylor, Colombo & Deretic, 2004; Levine, Mizushima & Virgin, 2011) . ATG16L1, the target gene of VDR and a regulator for autophagy, links VDR and autophagy (Wu & Sun, 2011) . Firstly, to confirm the function of ATG16L1, cells were treated with ATG16L1 siRNA ( Figure S3a ). The results showed that TNF-α and IL-6 levels in LPS cells decreased and AS promoting TNF-α and IL-6 levels in LPS tolerance cells were eliminated in ATG16L1 siRNA infected group relative to negative control (Figure 5a, S2a) . It suggests that ATG16L1 is associated with inflammatory cytokine release in LPS tolerance cells and AS's effects.

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