Selected article for: "cell priming and important role"
Author: Soto-Rodriguez, Guadalupe; Gonzalez-Barrios, Juan-Antonio; Martinez-Fong, Daniel; Blanco-Alvarez, Victor-Manuel; Eguibar, Jose R.; Ugarte, Araceli; Martinez-Perez, Francisco; Brambila, Eduardo; Millán-Perez Peña, Lourdes; Pazos-Salazar, Nidia-Gary; Torres-Soto, Maricela; Garcia-Robles, Guadalupe; Tomas-Sanchez, Constantino; Leon-Chavez, Bertha Alicia
Title: Analysis of Chemokines and Receptors Expression Profile in the Myelin Mutant Taiep Rat
  • Document date: 2015_3_25
    • ID: 0nb4laxz_2
    Snippet: Previous studies in the taiep rat have shown glial cell priming [3] , reactive astrogliosis since 1 month of age [9] , and lymphocyte infiltration at 6 months of age [4] , suggesting the participation of glial cells in the early age and leukocytes in the adulthood. To date, the immunological mediators involved in those differential cell processes in the taiep rat remain unknown. Several reports in different animal models [10] [11] [12] [13] [14] .....
    Document: Previous studies in the taiep rat have shown glial cell priming [3] , reactive astrogliosis since 1 month of age [9] , and lymphocyte infiltration at 6 months of age [4] , suggesting the participation of glial cells in the early age and leukocytes in the adulthood. To date, the immunological mediators involved in those differential cell processes in the taiep rat remain unknown. Several reports in different animal models [10] [11] [12] [13] [14] [15] and in human patients with MS [16] sustain the involvement of chemokines and their receptors in the CNS inflammation. Alternatively, chemokines also participate in myelin development. CXCL1 has been shown to play an important role in proliferation, differentiation, migration, and maturation of oligodendroglial cells and myelin synthesis [17] [18] [19] . Moreover, the deficit of CXCL1 and CXCR2 causes failure in the myelination process due to an aberrant migration of OPCs in the spinal cord white matter [20] . CXCL12 activating CXCR4 receptor has been involved in the OPCs maturation and remyelination failure [21] . CXCL12 also acts as a growth factor for stimulating the astrocyte proliferation and neuronal cells [22, 23] , via extracellular signal-regulated kinases (ERK 1/2) [24] .

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