Author: Soto-Rodriguez, Guadalupe; Gonzalez-Barrios, Juan-Antonio; Martinez-Fong, Daniel; Blanco-Alvarez, Victor-Manuel; Eguibar, Jose R.; Ugarte, Araceli; Martinez-Perez, Francisco; Brambila, Eduardo; Millán-Perez Peña, Lourdes; Pazos-Salazar, Nidia-Gary; Torres-Soto, Maricela; Garcia-Robles, Guadalupe; Tomas-Sanchez, Constantino; Leon-Chavez, Bertha Alicia
Title: Analysis of Chemokines and Receptors Expression Profile in the Myelin Mutant Taiep Rat Document date: 2015_3_25
ID: 0nb4laxz_20
Snippet: CCL19 is a chemokine involved in the maintenance of chronic neuroinflammation [30, 31] . Accordingly, this chemokine was upregulated in the brainstem of taiep rats. The CCR8 mRNA and protein were also upregulated at the age of 1 month in the taiep rats. This finding can explain the accumulation of microglial cells in the CNS of taiep rats reported previously [4] due to the action of promoting chemotaxis of mononuclear cells and phagocytosis [32] .....
Document: CCL19 is a chemokine involved in the maintenance of chronic neuroinflammation [30, 31] . Accordingly, this chemokine was upregulated in the brainstem of taiep rats. The CCR8 mRNA and protein were also upregulated at the age of 1 month in the taiep rats. This finding can explain the accumulation of microglial cells in the CNS of taiep rats reported previously [4] due to the action of promoting chemotaxis of mononuclear cells and phagocytosis [32] . However, CCR8 protein levels were decreased in 6-monthold taiep rats, suggesting decrease in the infiltration of macrophages.
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