Author: Soto-Rodriguez, Guadalupe; Gonzalez-Barrios, Juan-Antonio; Martinez-Fong, Daniel; Blanco-Alvarez, Victor-Manuel; Eguibar, Jose R.; Ugarte, Araceli; Martinez-Perez, Francisco; Brambila, Eduardo; Millán-Perez Peña, Lourdes; Pazos-Salazar, Nidia-Gary; Torres-Soto, Maricela; Garcia-Robles, Guadalupe; Tomas-Sanchez, Constantino; Leon-Chavez, Bertha Alicia
Title: Analysis of Chemokines and Receptors Expression Profile in the Myelin Mutant Taiep Rat Document date: 2015_3_25
ID: 0nb4laxz_1
Snippet: The taiep rats exhibit hypomyelination and suffer progressive demyelination resulting in a highly hypomyelinated central nervous system (CNS) as they reach adulthood [1, 2] . This demyelinating process has been associated with nitrosative stress in vivo and in vitro [3, 4] , glial-microglial activation and lymphocyte migration [4] , and an increase in lipoperoxidation, caspase-3 activation, and cell death in vivo [5] . The taiep rat has been cons.....
Document: The taiep rats exhibit hypomyelination and suffer progressive demyelination resulting in a highly hypomyelinated central nervous system (CNS) as they reach adulthood [1, 2] . This demyelinating process has been associated with nitrosative stress in vivo and in vitro [3, 4] , glial-microglial activation and lymphocyte migration [4] , and an increase in lipoperoxidation, caspase-3 activation, and cell death in vivo [5] . The taiep rat has been considered as a chronic animal model of multiple sclerosis (MS) [6] , which is characterized by a remyelination failure in areas of chronic demyelination with absence of oligodendrocyte progenitor cells (OPCs) and acute inflammation [7] . It has been suggested that astrogliosis in a microenvironment of chronic inflammation forms a barrier that impedes the OPC migration [7] . However, induction of an acute inflammation in areas of chronic demyelination can activate remyelination as proven in the taiep rat [8] . These results suggest that OPCs in the taiep rat are unable to generate myelinating oligodendrocytes due to the lack of the stimulatory factors and/or the presence of inhibitory factors [8] .
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