Author: Saeed, Abdullah F. U. H.; Wang, Rongzhi; Ling, Sumei; Wang, Shihua
Title: Antibody Engineering for Pursuing a Healthier Future Document date: 2017_3_28
ID: 0fegsm1v_32
Snippet: MAb characterization is based on a determination of its physicochemical and immunochemical character, heterogeneity, purity, impurities, biological activity, potency, and concentration (Berkowitz et al., 2012) . For physicochemical properties, the isotype (class, subclass, light chain composition) and primary structure of the mAb are determined. Immunological properties include binding assay, affinity, avidity, immunoreactivity (crossreactivity w.....
Document: MAb characterization is based on a determination of its physicochemical and immunochemical character, heterogeneity, purity, impurities, biological activity, potency, and concentration (Berkowitz et al., 2012) . For physicochemical properties, the isotype (class, subclass, light chain composition) and primary structure of the mAb are determined. Immunological properties include binding assay, affinity, avidity, immunoreactivity (crossreactivity with other structurally homologous proteins), analysis of CDR, epitope characterization, and determination of effector functions (CHMP, 2008) .
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