Author: Saeed, Abdullah F. U. H.; Wang, Rongzhi; Ling, Sumei; Wang, Shihua
Title: Antibody Engineering for Pursuing a Healthier Future Document date: 2017_3_28
ID: 0fegsm1v_54
Snippet: Different antibody fragments are used in phage display technology: scFv (single chain fragment variable), Fv (fragment variable), Fab (antigen binding fragment) and their derivatives, V-gene domain, bispecific or bivalent antibodies, and other oligomers (Figure 3 ; Nelson, 2010) . Fab fragments are the linkage of V H -C H and V L -C L by disulfide bridges, and radiolabeled Fabs are used in tumor imaging. Fv is used for the construction of V L and.....
Document: Different antibody fragments are used in phage display technology: scFv (single chain fragment variable), Fv (fragment variable), Fab (antigen binding fragment) and their derivatives, V-gene domain, bispecific or bivalent antibodies, and other oligomers (Figure 3 ; Nelson, 2010) . Fab fragments are the linkage of V H -C H and V L -C L by disulfide bridges, and radiolabeled Fabs are used in tumor imaging. Fv is used for the construction of V L and V H domains or their modifications such as scFv, which is the most popular fragment. A (Gly4Ser)3 linker is used for the stabilization of V L -V H and proper antigen binding site formation without the loss of antibody affinity. Chelating recombinant antibodies (CRAbs) are scFv segments with a high binding affinity. These constructs consist of two scFv fragments specific to the identical antigen and adjacent epitopes. These fragments are connected by a short linker (up to 10 amino acids) for the dimerization and formation of diabodies (Wright and Deonarain, 2007; Nelson, 2010) .
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