Author: Lum, Fok-Moon; Couderc, Thérèse; Chia, Bing-Shao; Ong, Ruo-Yan; Her, Zhisheng; Chow, Angela; Leo, Yee-Sin; Kam, Yiu-Wing; Rénia, Laurent; Lecuit, Marc; Ng, Lisa F. P.
Title: Antibody-mediated enhancement aggravates chikungunya virus infection and disease severity Document date: 2018_1_30
ID: 1vhzto1o_3
Snippet: is the most common mechanism in antibody-mediated enhancement of infections 22 . Monocytes express FcγRI and FcγRII equally (Fig. 1e) , while B cells express only FcγRII (Fig. 1f) . To investigate if FcγRs play a role in antibody-mediated enhancement, cells were pre-incubated with 10 μg of FcγR blocking agent prior to CHIKV infection under enhancement. Blocking of FcγRs significantly reduced the level of CHIKV antigen detected in monocytes.....
Document: is the most common mechanism in antibody-mediated enhancement of infections 22 . Monocytes express FcγRI and FcγRII equally (Fig. 1e) , while B cells express only FcγRII (Fig. 1f) . To investigate if FcγRs play a role in antibody-mediated enhancement, cells were pre-incubated with 10 μg of FcγR blocking agent prior to CHIKV infection under enhancement. Blocking of FcγRs significantly reduced the level of CHIKV antigen detected in monocytes (Fig. 1g) and B cells (Fig. 1h) .
Search related documents:
Co phrase search for related documents- CHIKV antigen level and FcγRs blocking: 1
- CHIKV infection and common mechanism: 1
- CHIKV infection and enhancement CHIKV infection: 1, 2, 3, 4, 5, 6, 7, 8, 9
- CHIKV infection and FcγRs blocking: 1, 2
- enhancement CHIKV infection and FcγRs blocking: 1, 2
Co phrase search for related documents, hyperlinks ordered by date